What is Fibrosing Mediastinitis?
Medistinal fibrosis is the common, but most severe, late complication of Histoplasmosis. Many Physicians believe mediastinal fibrosis to be an abnormal immunologic response to antigens released by the soil-based fungus Histoplasma capsulatum.
It should be differentiated from the many other less-severe mediastinal complications of histoplasmosis, and from other causes of mediastinal fibrosis, which are termed Idiopathic mediastinal fibrosis. Idiopathic fibrosing Mediastinitis is even less common, but may have multiple causes, none of which are related to histoplasmosis.
Accordingly, there are two types of fibrosing mediastinitis; histoplasmosis-related fibrosing mediastinitis, and idiopathic fibrosing mediastinitis which may have multiple causes unrelated to histoplasmosis.